Selected publications

2007-present

2004-2006

  1. Kapoor, T.M., Lampson MA, Hergert P, Cameron L, Cimini D, Salmon ED, McEwen BF, Khodjakov A. (2006) Chromosomes can congress to the metaphase plate before biorientation. Science, 311, 388-91.
  2. Kwok, B.H., Kapitein, L.C., Kim, J.H., Peterman, E.J., Schmidt, C.F. and Kapoor, T.M. (2006) Allosteric inhibition of kinesin-5 modulates its processive directional motility. Nature Chemical Biology, 2, 480-5.
  3. Gaetz, J., Gueroui, Z., Libchaber, A. and Kapoor, T.M. (2006) Examining how the spatial organization of chromatin signals influences metaphase spindle assembly. Nature Cell Biology, 8, 924-32.
  4. Peters, U., Cherian, J., Kim, J.H., Kwok, B.H. and Kapoor, T.M. (2006) Probing cell division phenotype space and Polo-like kinase functions using small molecule inhibitors. Nature Chemical Biology, 2, 618-26.
  5. Lampson, M.A, Renduchintala, K., Khodjakov, A. and Kapoor, T.M. (2004) Correcting improper chromosome-spindle attachments during cell division. Nature Cell Biology, 6, 232-7.
  6. Cochran, J.C., Sontag, C.A., Maliga, Z., Kapoor, T.M., Correia, J.J. and Gilbert, S.P. (2004). Mechanistic analysis of the mitotic kinesin Eg5. Journal of Biological Chemistry. 279, 38861-70.
  7. Gaetz, J. and Kapoor, T.M. (2004) Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles. Journal of Cell Biology, 166, 465-71.
  8. Mitchison, T.J. Maddox, P., Groen, A., Cameron, L., Perlman, Z., Ohi, R., Desai, A., Salmon, E.D. and Kapoor, T.M. (2004). Bipolarization and Poleward Flux Correlate during Xenopus Extract Spindle Assembly. Molecular Biology of the Cell, 15, 5603-15.
  9. Kwok, B.H., Yang, J.G. and Kapoor, T.M. (2004). The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5. Current Biology, 14, 1783-8.
  10. Solecki, D.J., Model, L., Gaetz, J., Kapoor, T.M., Hatten, M.E., (2004). Par6a signaling controls glial-guided neuronal migration. Nature Neuroscience, 7, 1195-203.
  11. Lampson, M.A and Kapoor, T.M. (2005). The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nature Cell Biology, 7, 93-98.
  12. Cochran, J.C., Gatiel, J.E., Kapoor, T.M., and Gilbert, S.P. (2005). Monastrol inhibition of the mitotic kinesin Eg5. Journal of Biological Chemistry. 280, 12658-67.
  13. Marcus, A.I., Peters, U., Thomas, S.L., Garrett, S., Zelnak, A., Kapoor, T.M., Giannakakou, P. (2005). Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells. Journal of Biological Chemistry, 280, 11569-77.
  14. Mitchison, T.J., Maddox, P., Gaetz, J., Groen, A., Shirasu, M., Desai, A., Salmon, E.D. and Kapoor, T.M. (2005). Roles of Polymerization Dynamics, Opposed Motors and a Tensile Element in Governing the Length of Xenopus Extract Meiotic Spindles. Molecular Biology of the Cell, In press (available online).
  15. Kapitein, L.C., Peterman, E.J.G., Kwok, B.H., Kim, J.H., Kapoor, T.M.* and Schmidt, C.F.* (2005). The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature, 434, 114-8. (*Equal contribution)

2002-2003

  1. Maliga, Z., Kapoor, T.M., and Mitchison, T.J. (2002). Evidence that Monastrol is an Allosteric Inhibitor of the Mitotic Kinesin Eg5. Chemistry and Biology, 9, 989-996.
  2. Garrett, S., Auer, K., Compton, D.A., and Kapoor, T.M. (2002) hTPX2 is Required for Normal Spindle Morphology and Centrosome Integrity during Vertebrate Cell Division. Current Biology, 12, 2055-2059.
  3. Khodjakov, A., Copenagle, L., Gordon, M.B., Compton, D.A. and Kapoor, T.M. (2003) Minus-end capture of pre-formed kinetochore fibers contributes to spindle morphogenesis. Journal of Cell Biology, 160, 671-683.
  4. Hotha, S., Yarrow, J.C., Yang, J.G., Garrett, S., Renduchintala, K.V., Mayer, T.U. and Kapoor, T.M. (2003) HR22C16: A potent small molecule probe for the dynamics of cell division. Angewandte Chemie International Edition, 42, 2379-2382.
  5. Canman, J.C., Cameron, L.A., Maddox, P., Tirnauer J., Straight, A.F., Mitchison, T.J., Fang, G., Kapoor, T.M., and E.D. Salmon (2003). Determing the position of the cell division plane. Nature, 424, 1074-8.

1999-2001

  1. Kapoor, T. M., and Mitchison, T. J. (1999). Allele-specific activators and inhibitors for kinesin. Proceedings of the National Academy of Sciences, USA, 96, 9106-9111.
  2. Mayer, T. U., Kapoor, T. M., Haggarty, S. J., King, R. W., Schreiber, S. L., and Mitchison T. J. (1999). A phenotype-based small molecule screen identifies an inhibitor of mitotic spindle bipolarity. Science, 286, 971-974.
  3. Kapoor, T. M., Mayer, T. U., Coughlin, M. L., and Mitchison, T. J. (2000). Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. Journal of Cell Biology, 150, 975-988.
  4. Kapoor, T. M. and Mitchison, T. J. (2001). Eg5 is static relative to tubulin in bipolar spindles: evidence for a static spindle matrix. Journal of Cell Biology, 154, 1125-1133.

Reviews

  1. Kapoor, T.M. and Compton, D.A. (2002). Searching for the middle ground: mechanisms of chromosome alignment during mitosis. Journal of Cell Biology, 157, 551-556.
  2. Garret, S. and Kapoor, T.M. (2003). Microtubule assembly: Catastrophe factors to the rescue. Current Biology, 13, R810-812.
  3. Peters, U. and Kapoor, T.M. (2004). New probes for microtubule dynamics. Chemistry and Biology, 11, 14-16.
  4. Kapoor, T.M. (2004). Chromosome segregation: Correcting improper attachment. Current Biology, 14, R1011-3.
  5. Lampson, M.A. and Kapoor, T.M. (2005). Unraveling cell division mechanisms with small-molecule inhibitors. Nature Chemical Biology, 2, 19-27.
  6. Khodjakov, A. and Kapoor, T.M. (2006). Microtubule flux: what is it good for? Current Biology, 15, R966-68.
  7. Lampson, M.A. and Kapoor, T.M. (2006). Targeting protein stability with a small molecule. Cell, 126, 827-9.
  8. Kwok, B.H. and Kapoor, T.M. (2007). Microtubule flux: drivers wanted. Current Opinion in Cell Biology, 19, 36-42.