Kapoor Lab
  • Home
  • Research
    • Areas
    • Highlights
    • Technologies
  • Publications
    • Featured
    • Chronology
  • People
    • Current Members
    • Past Members
    • Lab Fun
  • Contact

Publications

Featured

Picture
Kasap, C., Elemento, O., Kapoor, T.M. (2014), DrugTargetSeqR: a genomics- and CRISPR/Cas9-based method to analyze drug targets. Nature Chemical Biology, 10(8):626-8.
​
Wacker, S.A., Houghtaling, B.R., Elemento, O., 
Kapoor, T.M. (2012) Using transcriptome sequencing to identify mechanisms of drug action and resistance. Nature Chemical Biology, 8(3):235-237.
  • Determining a drug’s physiological target is a major challenge in chemical biology and drug discovery. Current strategies fall into two broad categories: model organism-based approaches and affinity-based methods (e.g. introducing a chemical handle for pull-downs followed by mass spectrometry). However, many drugs are not active in model organisms and affinity-based approaches are usually only effective when the drug is potent and the target is abundant in vivo...Read More 


Subramanian, R., Ti, S.C., Tan, L., Darst, S.A., Kapoor, T.M. (2013), Marking and measuring single microtubules by PRC1 and kinesin-4.  Cell, 145, 377-90.  (Highlighted in Developmental Cell, 26, 118) 
  • Nanometer-sized proteins generate micron-sized tags at distinct cellular sites to spatially regulate function across biology. Typically, such tags depend on proteins specifically recognizing structural features (e.g. DNA sequence at telomeres) that remain stable for periods that are much longer than protein association and activity timescales. However, it is unclear how proteins can selectively tag microtubules, which turnover on timescales faster than that of typical biochemical mechanisms (e.g. phosphorylation). To address this long-standing question, we focused on PRC1 and kinesin-4, two microtubule-associated proteins required to assemble the spindle midzone, a specialized array of microtubule bundles that keeps segregated chromosomes apart and positions the division plane in human cells... Read More
Picture

Firestone, A.J., Weinger, J.S., Maldonado, M., Barlan, K., Langston, L.D., O'Donnell, M., Gelfand, V.I., Kapoor. T.M.*, Chen, J.K.* (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature, 484, 125-9 [*corresponding authors] (Highlighted in Nature Reviews Drug Discovery, 11, 354; Nature Chemical Biology, 8, 503)  
  • Examining dynein functions in these diverse dynamic processes has been difficult using conventional approaches. In this report we describe the discovery of ciliobrevins, dihydroquinazolinone-based small molecules that are the first selective inhibitors of cytoplasmic dynein. We show that ciliobrevin treatment disrupts protein trafficking within the primary cilium and leads to shorter and malformed cilia. Consistent with these effects, Hedgehog signaling is blocked by ciliobrevins. These compounds also inhibit proper mitotic spindle assembly and block organelle transport in cultured cells...Read More

Picture
Shimamoto, Y., Maeda, Y.T., Ishiwata, S., Libchaber, A.J., Kapoor, T.M. (2011) Insights into the micromechanical properties of the metaphase spindle. Cell, 145, 1062-74. (Highlighted in Cell PaperFlick; Current Biology, 21(18), R688-R690)

  • The metaphase spindle must generate nanonewton-scale forces to pull chromosomes apart and must also be robust to withstand opposing forces of equal magnitude. Forces also act on the metaphase spindle to control its position and size. In addition, chromosomes, which are proportionately large cargoes, must be allowed to move through the spindle’s dense cytoskeletal polymer network. The forces associated with these chromosome motions exert deformations within the metaphase spindle. How this essential cellular structure maintains functional fidelity and structural stability in the face of these forces that can vary in magnitude, orientation and time-scales is poorly understood. To address this question we measured the orientation- and timescale-dependent micromechanical properties of the metaphase spindle...Read More


Subramanian, R., Wilson-Kubalek, E.M., Arthur, C.P., Bick, M.J., Campbell, E.A., Darst, S.A., Milligan, R.A., Kapoor, T.M. (2010) Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein. Cell. 142, 433-43. (Highlighted in Cell, Leading Edge Minireview, 142, 364-7; Nature Reviews Molecular Cell Biology, Research Highlight, 11, 602-603)

  • This study represents an important step in our efforts to reconstitute a ‘minimal mitotic spindle’ with purified proteins. The biophysical and structural characterization of the key non-motor microtubule-associated proteins (MAPs) required for cell division lags far behind that of motor proteins (e.g. kinesins). To fill this knowledge gap and to characterize the proteins needed for our reconstitution assays, we focused on PRC1. This non-motor MAP, or its homologs, is needed for normal cell growth in plants and fungi. In metazoans, PRC1 is needed for successful cell division. We combined X-ray crystallography, electron microscopy, and TIRF (total internal reflection fluorescence) microscopy approaches to analyze PRC1’s functions...Read More

Fuller, B.G., Lampson, M.A., Foley, E.A., Rosasco-Nitcher, S., Le, K.V., Tobelman, P., Brautigan, D.L., Stukenberg, P.T. and Kapoor, T.M. (2008) Midzone Activation of Aurora B in Anaphase Produces an Intracellular Phosphorylation Gradient. Nature, 453, 1132-6.
  • Error-free cell division depends on spatial and temporal cues regulating micron-scale organization. In current models, substrate phosphorylation plays a central role in generating these regulatory cues. While the kinase and phosphatase localizations during cell division have been extensively analyzed, the dynamics of phosphorylation remain poorly characterized. To fill this gap in our knowledge, we developed FRET-based sensors to examine in dividing cells the substrate phosphorylation dynamics that depend on Aurora kinase, a conserved cell cycle regulator in eukaryotes and an anti-cancer drug target...Read More
Picture

Bibliography
2010-2015

Hsia KC, Wilson-Kubalek EM, Dottore A, Hao Q, Tsai KL, Forth S, Shimamoto Y, Milligan RA, Kapoor TM  Reconstitution of the augmin complex provides insights into its architecture and function   NATURE CELL BIOLOGY 2014 SEP; 16(9):852-863 Full Text | PMID/PMCID

Kasap C, Elemento O, Kapoor TM   DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets   NATURE CHEMICAL BIOLOGY 2014 AUG; 10(8):626-U157 Full Text | PMID/PMCID

He M, Subramanian R, Bangs F, Omelchenko T, Liem KF, Kapoor TM, Anderson KV   The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment   NATURE CELL BIOLOGY 2014 JUL; 16(7):663-+ Full Text | PMID/PMCID

Sikirzhytski V, Magidson V, Steinman JB, He J, Le Berre M, Tikhonenko I, Ault JG, McEwen BF, Chen JK, Sui HX, Pie M,Kapoor TM, Khodjakov A   Direct kinetochore-spindle pole connections are not required for chromosome segregation  JOURNAL OF CELL BIOLOGY 2014 JUL 21; 206(2):231-243 Full Text | PMID/PMCID

Forth S, Hsia KC, Shimamoto Y, Kapoor TM   Asymmetric Friction of Nonmotor MAPs Can Lead to Their Directional Motion in Active Microtubule Networks   CELL 2014 APR 10; 157(2): Full Text | PMID/PMCID

Kashyap S, Sandler J, Peters U, Martinez EJ, Kapoor TM   Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors   BIOORGANIC & MEDICINAL CHEMISTRY 2014 APR 1; 22(7):2253-2260 Full Text |PMID/PMCID

Aoi Y, Sato M, Sutani T, Shirahige K, Kapoor TM, Kawashima SA   Dissecting the first and the second meiotic divisions using a marker-less drug-hypersensitive fission yeast   CELL CYCLE 2014 APR 15; 13(8):1327-1334 Full Text |PMID/PMCID

Takagi J, Itabashi T, Suzuki K, Shimamoto Y, Kapoor TM, Ishiwata S   Micromechanics of the Vertebrate Meiotic Spindle Examined by Stretching along the Pole-to-Pole Axis   BIOPHYSICAL JOURNAL 2014 FEB 4; 106(3):735-740 Full Text | PMID/PMCID

Subramanian R, Kapoor TM   Slipping past the spindle assembly checkpoint   NATURE CELL BIOLOGY 2013 NOV; 15(11):1261-1263 Full Text | PMID/PMCID

Takagi J, Itabashi T, Suzuki K, Kapoor TM, Shimamoto Y, Ishiwata S   Using Micromanipulation to Analyze Control of Vertebrate Meiotic Spindle Size   CELL REPORTS 2013 OCT; 5(1):44-50 Full Text | PMID/PMCID

Yi JS, Wu XF, Chung AH, Chen JK, Kapoor TM, Hammer JA   Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage   JOURNAL OF CELL BIOLOGY 2013 SEP 2; 202(5):779-792 Full Text |PMID/PMCID

Kleiner RE, Ti SC, Kapoor TM   Site-Specific Chemistry on the Microtubule Polymer   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2013 AUG 28; 135(34):12520-12523 Full Text | PMID/PMCID

Kleiner RE, Kapoor TM   Bumping Up Kinase Activity with an ATP-Derived Neo-Substrate   CELL 2013 AUG 15; 154(4):716-718 Full Text | PMID/PMCID

Liu X, Kapoor TM, Chen JK, Huse M   Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2013 JUL 16; 110(29):11976-11981 Full Text | PMID/PMCID

Li X, Foley EA, Kawashima SA, Molloy KR, Li YY, Chait BT, Kapoor TM   Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach   PROTEIN SCIENCE 2013 MAR; 22(3):287-295 Full Text | PMID/PMCID

Kawashima SA, Takemoto A, Nurse P, Kapoor TM   A Chemical Biology Strategy to Analyze Rheostat-like Protein Kinase-Dependent Regulation   CHEMISTRY & BIOLOGY 2013 FEB 21; 20(2):262-271 Full Text | PMID/PMCID

Foley EA, Kapoor TM   Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore  NATURE REVIEWS MOLECULAR CELL BIOLOGY 2013 JAN; 14(1):25-37 Full Text | PMID/PMCID

Subramanian R, Kapoor TM   Building Complexity: Insights into Self-Organized Assembly of Microtubule-Based Architectures   DEVELOPMENTAL CELL 2012 NOV 13; 23(5):874-885 Full Text | PMID/PMCID

Kawashima SA, Takemoto A, Nurse P, Kapoor TM   Analyzing Fission Yeast Multidrug Resistance Mechanisms to Develop a Genetically Tractable Model System for Chemical Biology   CHEMISTRY & BIOLOGY 2012 JUL 27; 19(7):893-901 Full Text | PMID/PMCID

Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK  Small-molecule inhibitors of the AAA plus ATPase motor cytoplasmic dynein   NATURE 2012 APR 5; 484(7392):125-129 Full Text | PMID/PMCID

Shimamoto Y, Kapoor TM   Microneedle-based analysis of the micromechanics of the metaphase spindle assembled in Xenopus laevis egg extracts   NATURE PROTOCOLS 2012 APR; 7(5):959-969 Full Text | PMID/PMCID

Wacker SA, Houghtaling BR, Elemento O, Kapoor TM   Using transcriptome sequencing to identify mechanisms of drug action and resistance   NATURE CHEMICAL BIOLOGY 2012 MAR; 8(3):235-237 Full Text | PMID/PMCID

Li X, Foley EA, Molloy KR, Li YY, Chait BT, Kapoor TM   Quantitative Chemical Proteomics Approach To Identify Post-translational Modification-Mediated Protein-Protein Interactions   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2012 FEB 1; 134(4):1982-1985 Full Text | PMID/PMCID

Tan L, Kapoor TM   Examining the dynamics of chromosomal passenger complex (CPC)-dependent phosphorylation during cell division   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011 OCT 4; 108(40):16675-16680 Full Text | PMID/PMCID

Foley EA, Maldonado M, Kapoor TM   Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase   NATURE CELL BIOLOGY 2011 OCT; 13(10):1265-U216 Full Text | PMID/PMCID

Li X, Kapoor TM   An Optical Switch for a Motor Protein   CHEMBIOCHEM 2011 OCT 17; 12(15):2265-2266 Full Text |PMID/PMCID

Wacker SA, Kashyap S, Li X, Kapoor TM   Examining the Mechanism of Action of a Kinesin Inhibitor Using Stable Isotope Labeled Inhibitors for Cross-Linking (SILIC)   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011 AUG 17; 133(32):12386-12389 Full Text | PMID/PMCID

Maldonado M, Kapoor TM   Moving Right Along: How PP1 Helps Clear the Checkpoint   DEVELOPMENTAL CELL 2011 JUN 14; 20(6):733-734 Full Text | PMID/PMCID

Shimamoto Y, Maeda YT, Ishiwata S, Libchaber AJ, Kapoor TM   Insights into the Micromechanical Properties of the Metaphase Spindle   CELL 2011 JUN 24; 145(7):1062-1074 Full Text | PMID/PMCID

Maldonado M, Kapoor TM   Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation   NATURE CELL BIOLOGY 2011 APR; 13(4):475-U291 Full Text | PMID/PMCID

Weinger JS, Qiu MH, Yang G, Kapoor TM   A Nonmotor Microtubule Binding Site in Kinesin-5 Is Required for Filament Crosslinking and Sliding   CURRENT BIOLOGY 2011 JAN 25; 21(2):154-160 Full Text | PMID/PMCID

Shimamoto Y, Kapoor TM   MECHANOREGULATION Cellular seat belts   NATURE 2010 NOV 25; 468(7323):518-519Full Text | PMID/PMCID

Subramanian R, Wilson-Kubalek EM, Arthur CP, Bick MJ, Campbell EA, Darst SA, Milligan RA, Kapoor TM   Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein   CELL 2010 AUG 6; 142(3):433-443 Full Text | PMID/PMCID

Tseng BS, Tan L, Kapoor TM, Funabiki H   Dual Detection of Chromosomes and Microtubules by the Chromosomal Passenger Complex Drives Spindle Assembly   DEVELOPMENTAL CELL 2010 JUN 15; 18(6):903-912 Full Text |PMID/PMCID

Wacker SA, Kapoor TM   Targeting a kinetochore-associated motor protein to kill cancer cells   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010 MAR 30; 107(13):5699-5700 Full Text | PMID/PMCID

Li X, Kapoor TM   Approach to Profile Proteins That Recognize Post-Translationally Modified Histone "Tails"   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2010 MAR 3; 132(8):2504-+ Full Text | PMID/PMCID

Islam K, Chin HF, Olivares AO, Saunders LP, De La Cruz EM, Kapoor TM   A Myosin V Inhibitor Based on Privileged Chemical Scaffolds   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2010; 49(45):8484-8488 Full Text | PMID/PMCID

2004-2009

Houghtaling BR, Yang G, Matov A, Danuser G, Kapoor TM   Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009 SEP 8; 106(36):15338-15343 Full Text | PMID/PMCID

Foley EA, Kapoor TM   Chromosome congression: on the bi-orient express   NATURE CELL BIOLOGY 2009 JUL; 11(7):787-789 Full Text | PMID/PMCID

Subramanian R, Kapoor T   Meiotic Spindle Self-Organization: One Plus One Equals Only One   CURRENT BIOLOGY 2009 APR 14; 19(7):R290-R292 Full Text | PMID/PMCID

Itabashi T, Takagi J, Shimamoto Y, Onoe H, Kuwana K, Shimoyama I, Gaetz J, Kapoor TM, Ishiwata S   Probing the mechanical architecture of the vertebrate meiotic spindle   NATURE METHODS 2009 FEB; 6(2):167-172 Full Text |PMID/PMCID

Kapitein LC, Kwok BH, Weinger JS, Schmidt CF, Kapoor TM, Peterman EJG   Microtubule cross-linking triggers the directional motility of kinesin-5   JOURNAL OF CELL BIOLOGY 2008 AUG 11; 182(3):421-428 Full Text | PMID/PMCID

Fuller BG, Lampson MA, Foley EA, Rosasco-Nitcher S, Le KV, Tobelmann P, Brautigan DL, Stukenberg PT, Kapoor TM  Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient   NATURE 2008 JUN 19; 453(7198):1132-U14 Full Text | PMID/PMCID

Yang G, Houghtaling BR, Gaetz J, Liu JZ, Danuser G, Kapoor TM   Architectural dynamics of the meiotic spindle revealed by single-fluorophore imaging   NATURE CELL BIOLOGY 2007 NOV; 9(11):1233-U45 Full Text

Loncarek J, Kisurina-Evgenieva O, Vinogradova T, Hergert P, La Terra S, Kapoor TM, Khodjakov A   The centromere geometry essential for keeping mitosis error free is controlled by spindle forces   NATURE 2007 NOV 29; 450(7170):745-U14 Full Text

Brennan IM, Peters U, Kapoor TM, Straight AF   Polo-Like Kinase Controls Vertebrate Spindle Elongation and Cytokinesis PLOS ONE 2007 MAY 2; 2(5):? Article e409 Full Text

Kwok BH, Kapoor TM   Microtubule flux: drivers wanted   CURRENT OPINION IN CELL BIOLOGY 2007 FEB; 19(1):36-42 Full Text

Peters U, Cherian J, Kim JH, Kwok BH, Kapoor TM   Probing cell-division phenotype space and Polo-like kinase function using small molecules   NATURE CHEMICAL BIOLOGY 2006 NOV; 2(11):618-626 Full Text

Lampson MA, Kapoor TM   Targeting protein stability with a small molecule   CELL 2006 SEP 8; 126(5):827-829 Full Text

Kwok BH, Kapitein LC, Kim JH, Peterman EJG, Schmidt CF, Kapoor TM   Allosteric inhibition of kinesin-5 modulates its processive directional motility   NATURE CHEMICAL BIOLOGY 2006 SEP; 2(9):480-485 Full Text

Gaetz J, Gueroui Z, Libchaber A, Kapoor TM   Examining how the spatial organization of chromatin signals influences metaphase spindle assembly   NATURE CELL BIOLOGY 2006 SEP; 8(9):924-U41 Full Text

Kapoor TM, Lampson MA, Hergert P, Cameron L, Cimini D, Salmon ED, McEwen BF, Khodjakov A   Chromosomes can congress to the metaphase plate before biorientation   SCIENCE 2006 JAN 20; 311(5759):388-391 Full Text

Lampson MA, Kapoor TM   Unraveling cell division mechanisms with small-molecule inhibitors   NATURE CHEMICAL BIOLOGY 2006 JAN; 2(1):19-27 Full Text

Khodjakov A, Kapoor T   Microtubule flux: What is it good for?   CURRENT BIOLOGY 2005 DEC 6; 15(23):R966-R968 Full Text

Mitchison TJ, Maddox P, Gaetz J, Groen A, Shirasu M, Desai A, Salmon ED, Kapoor TM   Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles  MOLECULAR BIOLOGY OF THE CELL 2005 JUN; 16(6):3064-3076 Full Text

Kapitein LC, Peterman EJG, Kwok BH, Kim JH, Kapoor TM, Schmidt CF   The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks   NATURE 2005 MAY 5; 435(7038):114-118 Full Text

Cochran JC, Gatial JE, Kapoor TM, Gilbert SP   Monastrol inhibition of the mitotic kinesin Eg5   JOURNAL OF BIOLOGICAL CHEMISTRY 2005 APR 1; 280(13):12658-12667 Full Text

Marcus AI, Peters U, Thomas SL, Garrett S, Zelnak A, Kapoor TM, Giannakakou P   Mitotic kinesin inhibitors induce mitotic arrest and cell death in taxol-resistant and -sensitive cancer cells   JOURNAL OF BIOLOGICAL CHEMISTRY 2005 MAR 25; 280(12):11569-11577 Full Text

Lampson MA, Kapoor TM   The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments  NATURE CELL BIOLOGY 2005 JAN; 7(1):93-+ Full Text

Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM   Bipolarization and poleward flux correlate during Xenopus extract spindle assembly   MOLECULAR BIOLOGY OF THE CELL 2004 DEC; 15(12):5603-5615 Full Text

Solecki DJ, Model L, Gaetz J, Kapoor TM, Hatten ME   Par6 alpha signaling controls glial-guided neuronal migration  NATURE NEUROSCIENCE 2004 NOV; 7(11):1195-1203 Full Text

Kwok BH, Yang JG, Kapoor TM   The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5   CURRENT BIOLOGY 2004 OCT 5; 14(19):1783-1788 Full Text

Cochran JC, Sontag CA, Maliga Z, Kapoor TM, Correia JJ, Gilbert SP   Mechanistic analysis of the mitotic kinesin Eg5  JOURNAL OF BIOLOGICAL CHEMISTRY 2004 SEP 10; 279(37):38861-38870 Full Text

Gaetz J, Kapoor TM   Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles   JOURNAL OF CELL BIOLOGY 2004 AUG 16; 166(4):465-471 Full Text

Lampson MA, Renduchitala K, Khodjakov A, Kapoor TM   Correcting improper chromosome-spindle attachments during cell division   NATURE CELL BIOLOGY 2004 MAR; 6(3):232-237 Full Text

Peters U, Kapoor TM   New probes for microtubule dynamics  CHEMISTRY & BIOLOGY 2004 JAN; 11(1):14-16 Full Text

2001-2003

Garrett S, Kapoor TM   Microtubule assembly: Catastrophe factors to the rescue   CURRENT BIOLOGY 2003 OCT 14; 13(20):R810-R812 Full Text

Canman JC, Cameron LA, Maddox PS, Straight A, Tirnauer JS, Mitchison TJ, Fang GW, Kapoor TM, Salmon ED  Determining the position of the cell division plane   NATURE 2003 AUG 28; 424(6952):1074-1078 Full Text

Khodjakov A, Copenagle L, Gordon MB, Compton DA, Kapoor TM   Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis   JOURNAL OF CELL BIOLOGY 2003 MAR 3; 160(5):671-683 Full Text

Hotha S, Yarrow JC, Yang JG, Garrett S, Renduchintala KV, Mayer TU, Kapoor TM   HR22C16: A potent small-molecule probe for the dynamics of cell division   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2003; 42(21):2379-2382 Full Text

Garrett S, Auer K, Compton DA, Kapoor TM   hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division   CURRENT BIOLOGY 2002 DEC 10; 12(23):2055-2059 Full Text

Maliga Z, Kapoor TM, Mitchison TJ   Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5  CHEMISTRY & BIOLOGY 2002 SEP; 9(9):989-996 Full Text

Kapoor TM, Compton DA   Searching for the middle ground: mechanisms of chromosome alignment during mitosis  JOURNAL OF CELL BIOLOGY 2002 MAY 13; 157(4):551-556 Full Text

Kapoor TM, Mitchison TJ   Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix  JOURNAL OF CELL BIOLOGY 2001 SEP 17; 154(6):1125-1133 Full Text
Proudly powered by Weebly